Research Areas
Medicinal Chemistry
Structure-activity relationships
Structure-Based Drug Design
Fragment-Based Drug Design
Serine protease
inhibitors (thrombin, Factor X, C1s, DPP IV, chymase, cathepsin
G, and others)
Cysteine protease
inhibitors (confidential)
Metalloprotease
inhibitors (MMP1, MMP-3, MMP9, MMP13)
Tyrosine kinase
inhibitors (FMS and others)
GPCR antagonists
(Integrin, CCR2, HDM2, neurokinin, benzodiazepine)
Chemogenomics
Biological Knowledge
Target ID and validation
(Conditional KO, KO, siRNA)
Pathway analysis
HTS
Biochemical and
cellular assays
Pharmacological
models in Inflammation, Oncology, CV, and CNS
Systems biology
approaches
Drug Metabolism
Caco-2 permeability
Cyp P450 induction/inhibition
Microsomal stability
Pharmacokinetics (Win NonLin)
PK/PD relationships
Pharmaceutical Science
Formulation optimization (HPbCD,
Captisol, etc)
Crystallization optimization
Nanosizing
Co-crystallization
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